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Beilstein J. Org. Chem. 2015, 11, 2654–2660, doi:10.3762/bjoc.11.285
Graphical Abstract
Figure 1: Structure of PGI2 and beraprost (1).
Scheme 1: Retrosynthetic analysis of beraprost (1).
Scheme 2: Preparation of Michael precursors 7 and 8.
Scheme 3: First attempt at the synthesis of 2 from 6.
Scheme 4: Achievement of a formal synthesis of 2.